Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells
نویسندگان
چکیده
منابع مشابه
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization
Retinoid X receptors (RXRs) play key roles in many physiological processes in both the periphery and central nervous system. In addition, RXRs form heterodimers with other nuclear receptors to exert their physiological effects. The nuclear receptor related 1 protein (NURR1) is particularly interesting because of its role in promoting differentiation and survival of dopamine neurons. However, on...
متن کاملStructural Determinants of Allosteric Ligand Activation in RXR Heterodimers
Allosteric communication underlies ligand-dependent transcriptional responses mediated by nuclear receptors. While studies have elucidated many of the components involved in this process, the energetic architecture within the receptor protein that mediates allostery remains unknown. Using a sequence-based method designed to detect coevolution of amino acids in a protein, termed the statistical ...
متن کاملPPAR /RXR Heterodimers Control Human Trophoblast Invasion
The ligand-dependent nuclear receptors PPAR and RXR / were recently determined to be essential for murine placental development and trophoblast differentiation. In the current study we examined the expression and role of the PPAR / RXR heterodimers in human invasive trophoblasts. We first report that in human first trimester placenta, PPAR and RXR are highly expressed in cytotrophoblasts at the...
متن کاملThe RXR heterodimers and orphan receptors
The nuclear receptor superfamily is comprised of over 150 different proteins that have evolved to mediate a complex array of extracellular signals into transcriptional responses. Many, but not all, of these proteins directly bind to signaling molecules, which, because of their small lipophilic character, can easily enter the target cell. Thus, unlike membrane-bound receptors, the nuclear recept...
متن کاملRAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury
The retinoid acid receptors (RAR) and peroxisome proliferator-activated receptors (PPAR) have been implicated in the regulation of inflammatory reactions. Both receptor families contain ligand-activated transcription factors which form heterodimers with retinoid X receptors (RXR). We review data that imply RAR/RXR and PPAR/RXR pathways in physiological reactions after spinal cord injury. Experi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 2003
ISSN: 0890-9369
DOI: 10.1101/gad.276003